Proteomics and Mass Spectrometry
Institute of Pharmacology & Structural Biology (CNRS-IPBS)
David Bouyssié is an expert in computational proteomics. He has more than 15 years of experience developing tools and algorithms for the quantification of peptides and proteins from LC-MS/MS raw data (HDX-Viewer, MFPaQ, Proline). He is also one of the creators of the mzDB file format, which has been conceived to speed-up the analysis and the visualization of large MS datasets. David holds a permanent research engineer position at the Proteomics Infrastructure of Toulouse. He is also a board member of the French Proteomics Society (FPS) and is a founding member of the EuBIC-MS initiative (https://eubic-ms.org/).
The Proteomics and Mass Spectrometry laboratory headed by Odile Burlet-Schiltz at the Institute of Pharmacology and Structural Biology is engaged in several research projects and is also hosting a high-end facility equipped with state-of-the-art MS instrumentation and bioinformatics tools. It is recognized at the national level as part of the Proteomics French Infrastructure, ProFI.
Their main research projects focus on the characterization of human proteasome complexes to understand their structure-function relationships and on the in-depth analysis of proteomes of various cells from the immune system to understand their specific role and to decipher signaling events. The group has gained worldwide recognition for its expertise in several aspects of MS-based proteomics (interactomics, phosphoproteomics, large-scale quantitative proteomics) and the development of innovative bioinformatics tools. Its long-lasting expertise in bottom-up proteomics has more recently been complemented by new skills in structural MS.